r/science • u/mvea Professor | Medicine • Feb 21 '25
Neuroscience The risk of developing ADHD was 3 times higher among children whose mothers used the pain-relief drug acetaminophen (paracetamol) during pregnancy. The association was stronger among daughters, with the daughters of acetaminophen-exposed mothers showing a 6.16 times higher likelihood of ADHD.
https://newsroom.uw.edu/news-releases/child-adhd-risk-linked-to-mothers-use-of-acetaminophen
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u/Lotek-machine Feb 21 '25
I would not be so quick to jump dismissing their research as “correlation not causation” . 1.This was published in Nature- a top journal. 2. The Discussion section of the paper addresses this concern as a limitation. And 3. IMO what’s most compelling and worthy of consideration is that the genetic bio makers they found in the human placenta correlating With apap and adhd matches up with the bio markers for a adhd/ apap correlation in rats. This substantially strengthens the argument for causality . https://www.nature.com/articles/s44220-025-00387-6.epdf?sharing_token=fpUlNtr8PZtuQJtUSf-wE9RgN0jAjWel9jnR3ZoTv0PnoSLx7AIUTNabJRwiEKQOWz8csjJ5cVkMOuqaFVOs53Puzs6pPMlNfC1bc1e6i2XsEMvfwVTOSR3PCTRT8PeeWFFxtZrxzxm4lNpV1T-SInMIfp6TbyJmVdJvgGen8iQ%3D