r/science • u/mvea Professor | Medicine • Oct 09 '24

Neuroscience Giving psilocybin, the psychedelic in magic mushrooms, to rats made them more optimistic in the longer term, suggesting that the psychedelic substance could have great potential in treating a core symptom of depression in humans.

https://newatlas.com/medical/psilocybin-optimism-depression/
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u/hummelaris Oct 09 '24

Been struggling with depression as an autistic person my whole life. A couple of months ago i ordered microdose truffels and did that for two months. Something in my head has clicked, i dont know what but it is still changing my life. I am much more positive thinking and it doesnt go away. For me its been life changing in the way i think and process negative thoughts.

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u/reddit_crunch Oct 09 '24

honestly psychedelics have done something to me too, i don't even recognise my old negative perspective anymore. i can still see so much in the world is in a dire state but there's a sense of deep wonder and curiosity awakened in me now that makes me think even the misery is in service of a abiding universal positivity, or at latest, balance. it's like 'the egg' by andy weir but i truly grok it now.

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u/hummelaris Oct 09 '24

Same here man same here, sometimes i still cannot believe i am so much more stable in my thinking. I hope it lasts, thats my only fear..

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u/afig24 Oct 09 '24

Where do you guys get your product? Online? Can you recommend some good companies/vendors?

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u/thejaytheory Oct 09 '24

I get mine from a good plug.

3

u/growerdan Oct 09 '24

Are you in the US? Go to a cannabis convention they usually sell them there. Even if cannabis isn’t legal in your state I bet they have conventions where they sell it to anyone. I don’t understand how it works when it’s illegal but that’s been my source. Then you can get business cards from all kinds of local mom and pop businesses that grow their own and make edibles.

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u/Grub-lord Oct 09 '24

Thats because those things usually are not mushrooms or even psilocybin. Theyre usually chocolates infused with some sort of 'grey zone' research chemical that is (currently) legal. Not saying it wont get the job done, but most of these pre-packaged chocolates in the USA are legal only because they are lying about what's in them.

1

u/alsocolor Oct 09 '24

In DC they’re legal and you can buy them from dispensaries!

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u/EetsGeets Oct 09 '24

What was the dosing of the truffles?

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u/chantillylace9 Oct 09 '24

If it doesn’t work, I highly recommend ketamine therapy. It literally changed my life, cured my anxiety and was able to re-wire my thinking completely. I tried medication and therapists and supplements and every self-help book under the sun and nothing works like a few sessions of ketamine therapy.

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u/hummelaris Oct 09 '24

Ok thx, i will look into that. Dont know if its a known therapy here in belgium.

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u/chantillylace9 Oct 09 '24

There is a therapeutic ketamine forum on Reddit, that’s the actual name, and if you search you might be able to find if there is any treatment available in Belgium.

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u/Heizenbrg Oct 09 '24

Happy for you, it has worked with me at high doses with IV infusion but expensive. The troches don’t hit the same

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u/chantillylace9 Oct 09 '24

Have you tried Spravato nasal spray?

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u/Heizenbrg Oct 11 '24

No I haven’t why?

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u/chantillylace9 Oct 11 '24

Because it’s covered by insurance!

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u/bodez95 Oct 09 '24

How long is the treatment and how long do the results last in your experience?

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u/chantillylace9 Oct 09 '24

So you can either do IV, nasal spray, or lozenges at home. I did the lozenges at home and it takes about an hour and a half or so for each session.

The results vary, if you do IV it usually lasts a few months. I do it twice a week and that seems about right for me. Some people do every single day low-dose but it’s hard to set aside that much time.