Boosting brain’s waste removal system improves memory in old mice | Researchers found that rejuvenating the lymphatic vessels in the brain enhanced recognition memory and restored synaptic function through an interleukin-6 (IL-6) pathway.

[u/Potential_Being_7226]

https://medicine.washu.edu/news/boosting-brains-waste-removal-system-improves-memory-in-old-mice/

[u/Potential_Being_7226]

From the press release:

Aging compromises the lymphatic vessels (green) in tissue called the meninges (blue) surrounding the brain, disabling waste drainage from the brain and impacting cognitive function. Researchers at WashU Medicine boosted lymphatic vessel integrity (bottom) in old mice and found improvements in their memory compared with old mice without rejuvenated lymphatic vessels (top). 

As aging bodies decline, the brain loses the ability to cleanse itself of waste, a scenario that scientists think could be contributing to neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease, among others. Now, researchers at Washington University School of Medicine in St. Louis report they have found a way around that problem by targeting the network of vessels that drain waste from the brain. Rejuvenating those vessels, they have shown, improves memory in old mice.

Publication in Cell:

DOI: 10.1016/j.cell.2025.02.02200210-7?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S0092867425002107?showall=true)

[u/Mokyzoky → u/Potential_Being_7226]

Please fix my brain my memory is actually so bad

[u/realitythreek → u/Mokyzoky]

Friend, I recently was diagnosed with ADHD and having a poor memory was a symptom. I’m taking medication for it and my memory has actually improved at 44 rather than gotten worse.

[u/Mokyzoky → u/realitythreek]

What did you start taking? I’ve been off medication for years although I am diagnosed I’m looking at getting back on it.

[u/realitythreek → u/Mokyzoky]

I’m taking welbutrin and it’s worked well for me but I’ve heard good things about straterra too. Pretty life changing for someone that’s always just coped (not entirely successfully).

[u/Mokyzoky → u/realitythreek]

I’ve been on Wellbutrin too for a while and it’s totally improved things I would like to mix it with one of the stims preferably the most tame one

[u/GayBitchJuice → u/Mokyzoky]

How long did wellbutrin take to have effect for you guys? I’m at 150mg for 3 weeks and not feeling much

[u/realitythreek → u/GayBitchJuice]

For me it was about 4 days, but I’m actually taking 300mg now. The 150mg I seemed to metabolize too quickly.

[u/Mokyzoky → u/GayBitchJuice]

I’m also taking 300mg Wellbutrin google how it works on your brain and it will make sense. You won’t notice it start to work until you realize you’re doing things that you normally struggle to do before. And at three weeks, it’ll just be beginning to work. So give it some time and maybe up your dose.

[u/LearningIsTheBest → u/realitythreek]

Is there medicine actually in stock for new patients?

[u/realitythreek → u/LearningIsTheBest]

There’s non-stimulant meds you can take, I’ve not had that issue but I know the stimulant meds can be pretty hard to get. I’m taking Welbutrin but there’s a few others.

[u/LearningIsTheBest → u/realitythreek]

Thanks for the suggestion :)