Boosting brain’s waste removal system improves memory in old mice | Researchers found that rejuvenating the lymphatic vessels in the brain enhanced recognition memory and restored synaptic function through an interleukin-6 (IL-6) pathway.

[u/Potential_Being_7226]

https://medicine.washu.edu/news/boosting-brains-waste-removal-system-improves-memory-in-old-mice/

[u/IOnlyLiftSammiches]

Could be the difference between those that get a "runner's high" from exercise vs those that don't. If I'm going to have to stay awake for longer than normal (adjusting for swing shifts), I plan for my exercise to take place before the last 6-8 hours of that because it gives me such a mental and physical energy boost.

[u/deanusMachinus → u/IOnlyLiftSammiches]

Doesn’t everyone get a runner’s high if you run long enough? It just takes 20+ mins of running and most people can’t do that.

[u/ClutchCobra → u/deanusMachinus]

I honestly think some people don't, maybe it's a genetic thing, maybe it's a learned thing, but some are adamant that exercise them discomfort.

And it would really suck for that to be your experience. I couldn't imagine exercising without that rush on endorphins and confidence. It's gotten to the point where my energy levels paradoxically tank on the days I don't exercise. If I'm working a long shift I feel twice as alert throughout the day when I've exercised before

[u/Primeval_Revenant → u/ClutchCobra]

Back when I was actively exercising regularly there was not a single time where I felt anything but exhaustion and aches. I was just going through it all with the mantra of ‘Do this to be healthy.’ running through my mind constantly and that was NOT encouraging at all. A big factor of why I stopped. It became a greater drain on me than any benefits I was observing (which was probably a purely psychological thing, as there were probably great benefits, but that is just how a mind works).