Boosting brain’s waste removal system improves memory in old mice | Researchers found that rejuvenating the lymphatic vessels in the brain enhanced recognition memory and restored synaptic function through an interleukin-6 (IL-6) pathway.

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https://medicine.washu.edu/news/boosting-brains-waste-removal-system-improves-memory-in-old-mice/

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There’s evidence that sleeping pills inhibit our brains waste disposal: https://www.sciencenews.org/article/sleeping-pills-brain-effects