I have been taking this pill with probiotics (you look well day pill) for about 2 weeks, my stomach settled about 4 days in but it feels like it is getting worse now - Burning acid reflux type pain in my stomach. Should i continue and push through in the hopes it will improve?

https://theconversation.com/why-we-should-all-try-to-eat-like-people-in-rural-papua-new-guinea-new-study-248064

I’ve been having trouble putting on weight , mostly because of my fiber intake - 40g a day.. so I’m gonna try lowering to 20-25 with just more fermented foods ie kimchi instead of broccoli

I suddenly developed constipation 5 months after contracting ghsv1 and after a 2 week alchohol binge and it hasn’t gotten better since. I feel like my food just sits in my stomach , I don’t have a urge to poop but when I do poop it’s soft loose stools . I burp all day and have really smelly gas . When I do an enema there’s barely anything that comes out , laxatives rarely work. I noticed there’s undigested food in my stool and sometimes my stool is green . I got a colonoscopy and my colon is fine they say. I’ve been doing research I know about sibo etc, which I’m sure could be a factor. All the doctors wanna do I put me on miralax and linzess which doesn’t work .

12 days ago i had food poisoning from raw milk (i believe i got campylobacter if i remember correctly what the doctor said)

i had fever first 2 days then bloody diarrhea for a few days once the fever passed

my stool color turned normal but i had stomach cramps while pooping up to like day 9

doctor only prescribed me with a stomach relaxer

the only symptoms i have left now is white specks in my stool and an ithcy anus from time to time

im paranoid this could be the start of an autoimmune / chronic disease and that my symptoms might show up again since reading that food poisoning can be the start of life long digestive diseases

Do they actually get to where they need to go or is it just wasting money.

EDIT: I really appreciate everyone's responses! Thank you all so much.

So I got banned for posting a question about this subject (title) by a mod that said that I had no right to post about something that is completely experimental, dangerous and something about blackmarket drugs ( I did not mention anything on this matter). I received 3 total replies before being banned and here is the reply for those who are more interested; Yes there is science to back this up. Here are some articles to prove it.

1. https://www.nature.com/articles/pr199587?utm_source=chatgpt.com

2. https://pmc.ncbi.nlm.nih.gov/articles/PMC1027008/?utm_source=chatgpt.com

3. https://www.scielo.br/j/bjmbr/a/gwPSm3TPWBfTB4j8YdDThkH/?utm_source=chatgpt.com

4. https://pubmed.ncbi.nlm.nih.gov/16083754/?utm_source=chatgpt.com

Study description:

1. Small Intestine:

Intestinal Ion Transport: A study published in Pediatric Research examined the acute administration of hGH on rat ileum. The results indicated that hGH rapidly increased the absorption rates of water, sodium, chloride, and potassium. In vitro experiments showed that hGH decreased transepithelial potential difference and short-circuit current, suggesting an inhibition of basal active chloride secretion. These findings suggest that hGH has a direct antisecretory effect on the intestine, enhancing its absorptive function.

Mucosal Growth and Proliferation: Research published in Gut explored the trophic actions of hGH, insulin-like growth factor-I (IGF-I), and insulin on human duodenal mucosa cultured in vitro. The study found that all three hormones significantly increased crypt epithelial cell proliferation, with IGF-I being the most potent. This indicates that hGH and its mediators play a role in regulating cell proliferation in the human small intestine.

Intestinal Barrier Function in Sepsis: A study in the Brazilian Journal of Medical and Biological Research investigated the effects of recombinant human growth hormone (rhGH) on the intestinal mucosa barrier in septic rats. The results demonstrated that rhGH attenuated intestinal mucosal injuries and bacterial translocation. Additionally, rhGH influenced the expression of proteins related to apoptosis, suggesting a protective role in maintaining intestinal integrity during sepsis.

Post-Trauma Intestinal Homeostasis: Research in PubMed assessed the impact of growth hormone on gut mucosal homeostasis after severe trauma. The study found that while hGH did not significantly affect small bowel epithelial cell apoptosis or proliferation, it improved villous morphology, indicating a role in maintaining intestinal structure post-injury.

1. Pancreas:

While the provided studies primarily focus on the intestines, research indicates that hGH can influence pancreatic function. hGH has been shown to induce insulin resistance in peripheral tissues, prompting the pancreas to increase insulin secretion to maintain glucose homeostasis. Over time, this increased demand may stress pancreatic β-cells.

1. Colon:

Specific studies directly examining the effects of hGH on the colon are limited. However, the general trophic effects of hGH on intestinal mucosa suggest potential influences on colonic tissues, warranting further investigation.

Hello everyone,

Does anyone know of an antinutrient-free oat alternative?

Due to intestinal problems and food allergies,

I'm currently switching my diet to only natural foods.

I used to eat oatmeal with yogurt, wild blueberries, and honey, but the antinutrients in oatmeal are causing me major problems (gluten isn't a problem for me).

I'm happy to hear any suggestions.

I’ve started a one week course of amoxicillin and am 4 days in. 500mg three times a day. It just started today but I get whiffs of smoke/campfire that no else seems to smell. Has anyone else experienced random smells when on amoxicillin. Of course google says brain tumor so that didn’t help.

After a year and a half of treating disbiosis with no favorable results I have decided to do a human growth hormone cycle that will last about 4-5 months. There are endless reasons to why I'm enthusiastic about this non-conventional treatment. If you have any insights on this matter; somatropin v gut microbiome please share. Thanks

Hi! I started using colostrum from a well know brand a few months ago and while I haven’t had any negative side effects, I haven’t really noticed a huge difference. Anyone have experience using colostrum? What should I be looking out for?

I’ve recently got rid of sibo (thank god).

Now is time for me to fix my histamine intolerance. For those who had success with custom probiotics D lactate free or a similar probiotic, what sort of timeline did you have for fixing histamine intolerance?

I’ve started cautiously (1/8th baby scoop), only 2 days in and have had some increased histamine response, which is annoying but I’m not concerned about. Particularly not concerned because 1/8th baby scoop when I had sibo sent me insane and didn’t let me sleep for days, whereas I can sleep after taking the custom probiotics now.

Overall, what sort of thing should I be expecting, how long did it take to help you?

Hello everyone. I'm in desperate need for help and I have been for too long now. I believe there's something really wrong in my stomach, and I'm just barely staying alive right now. I'm trying to help myself by figuring out what is wrong with me. My doctor doesn't believe me - she's called my issues psychological for over 6 months now. I have to save myself somehow. Will list symptoms and if anyone had any guidance or ideas about what's going on with me I'll be forever grateful. 😓

I'm a 37 year old female. Previously very healthy and active. 6 months ago I got a pneumonia and insane symptoms have since followed. I now have suspected Pots, a small hiatal hernia and esophagitis.

SYMPTOMS:

• Neurological issues when I swallow anything (skin burning/stinging)
• Overheat when eating ANYTHING
• Joint and bone pain
• Episodes where I wake up and my skin has become dry and flaky over night, and I pee like crazy
• Very upset stomach, always runny or constipated
• Stomach burns like fire near the ribs when I eat
• Tight throat
• Migraines from hell
• Swollen and red tonsils and sometimes swollen/white tongue but negative for candida several times.
• Periodically extreme fatigue
• Have had hypokalemia 5 times during these 6 months
• I'm either freezing or boiling up, seem intolerant to temperature changes
• Low grade fevers randomly
• Random anxiety attacks for no reason
• Acne prone
• Sometimes it burns when I pee when I'm in a flare but no UTI or STD etc.

My very first symptoms started in my stomach, and it feels like something is very wrong there. I've had upper endoscopy but they couldn't do a biopsy because the air they blow in just shot straight out of me and I was throwing up loads.

THINGS I'VE DONE MYSELF:

• Tried elimination diet but nothing helps
• Tried to stay hydrated with fizzy tablets
• Gone to several different doctors and had overnight stays at hospital for potassium IV.
• Tried low histamine diet ( no difference )
• Tried taking antihistamines and pepcid ( since many people have previously mentioned MCAS but no difference)
• Tried water fasting which helped symptoms after 4 days but only for a few days until I flared again.
• Scheduled an endoscopy to check bowels
• Scheduled at cardio for Pots

If anyone has any idea or recognises symptoms, please share anything and everything you can. This is intolerable, I'm barely functional at this point and the neurological pain hurts so so bad. I'm helpless and I live in Sweden so the doctor's here don't test for things like Sibo or leaky gut. I need all the help I can get. 🌷 I don't want to live in my own body anymore.

I have always had bad breath.

I have visited dentists, ENT specialists and gastroenterologists. Dentists and ENT specialists have ruled out complications. So it is presumed to be a gastroenterological problem.

My symptoms are: bad breath, slightly white tongue (it is not candida according to the ENT specialist).
It seems to me that bad breath gets worse during the digestive phases.

I have impeccable oral hygiene. Dental floss, I go to the dental hygienist every six months, waterpick, I brush my tongue etc.

What tests have I done: Helicobacter pylori test, SIBO test, abdominal ultrasound, blood tests, stool tests, food intolerances, lactose test, celiac disease test, stomach acidity test, ENT specialist ruled out the presence of tonsil stones.

These tests only revealed a dysbiosis that I have healed.

What I tried: no carb diet, no dairy diet, took enzymes, ppi, nasal washes, motility medications, castile soap.

The situation is slightly improved but not cured.

What is left for me to try?

What could be the cause?

Can anyone relate or is it all in my head. I took fulvic acid a few months to help with digestive health but I think it affected my vision. The world around me seems cloudy and not real. When I google the symptoms derealization comes up but I’ve never had an issue with anxiety or depression. The world looks different now, feels like I’m in a dream. So far I haven’t spoken to anyone who had similar side effects. My optometrist said my vision was still perfect

Back again! Prior two editions can be found here & Here

Thanks everyone for the positive comments so far. If anyone has any feedback let me know. I might also put these into a companion substack.

Article: Lactobacillus Johnsonii YH1136 alleviates schizophrenia-like behavior in mice: a gut–microbiota–brain axis hypothesis study | BMC Microbiology | Full Text

Summary

• The administration of Lactobacillus johnsonii YH1136 decreased schizophrenia-like behaviors in a mouse model, suggesting its potential as a therapeutic for SCZ via gut microbiome modulation
• Significant alterations in serum metabolites were noted between control and SCZ groups, highlighting the metabolic dysregulation associated with schizophrenia.
  • Over 900 metabolites were identified in serum samples, revealing significant metabolic changes linked to schizophrenia and L. johnsonii treatment.
• Probiotic treatment improved both locomotor activity and social interaction capabilities in mice with schizophrenia-like symptoms.
  • Mice treated with Lactobacillus johnsonii showed significant behavioral improvements in tests like the elevated plus maze and open field test.
• L. johnsonii may influence neurochemical pathways involved in mood regulation and cognitive function through gene expression related to tryptophan metabolism.

Article: Systematic review: The gut microbiota as a link between colorectal cancer and obesity - Ruiz‐Malagón - 2025 - Obesity Reviews - Wiley Online Library

Summary

• The review highlights a significant link between gut microbiota dysbiosis and an increased risk of colorectal cancer (CRC) in individuals with obesity.
  • Colorectal cancer accounts for approximately 10% of all cancer cases worldwide and is the second leading cause of cancer-related mortality.
• Chronic inflammation related to obesity is a pivotal mechanism that heightens colorectal tumorigenesis through elevated adipokines and pro-inflammatory mediators.
  • Obesity contributes to a 30-70% increased risk of developing colorectal cancer, often linked to changes in the gut microbiome.
• Microbiota-derived metabolites like SCFAs and LPS are crucial in cancer development and progression associated with obesity.
• The connection between dysbiosis, obesity, and CRC emphasizes the potential for microbiome-targeted therapies, such as probiotics or dietary changes, to prevent or treat cancer in high-risk individuals.

1. Research indicates significant alterations in microbial composition in both obesity and CRC, with specific bacteria linked to either healthy states or increased cancer risk.

Article: Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatments - Podwojniak - 2025 - Journal of the European Academy of Dermatology and Venereology - Wiley Online Library

Summary

• Current acne treatments have limitations, fostering interest in targeting the cutaneous microbiome as a complementary approach.
  • Cutaneous Microbiome: The diverse community of microorganisms on the skin's surface, influencing skin health.
• Alterations in the cutaneous microbiome—specifically in species richness and diversity—are linked to acne severity and treatment response.
  • Meta-analyses indicate that benzoyl peroxide treatment significantly decreases alpha diversity, suggesting a shift in microbial composition with acne therapy.
• Probiotics and natural compounds hold promise as treatments by modulating the cutaneous microbiome and reducing inflammation.
• Significant reductions in alpha diversity were seen after certain acne treatments, indicating the need for personalized approaches based on individual microbiome profiles.

Article: Faecalibacterium prausnitzii-derived outer membrane vesicles reprogram gut microbiota metabolism to alleviate Porcine Epidemic Diarrhea Virus infection | Microbiome | Full Text

Summary

• The study demonstrates that Faecalibacterium prausnitzii-derived outer membrane vesicles significantly reprogram gut microbiota metabolism to alleviate the effects of Porcine Epidemic Diarrhea Virus infection in a piglet model.
• Metabolomic analysis revealed an enrichment of phosphatidylcholine and its derivatives following the treatment with F. prausnitzii OMVs, suggesting a crucial role in modulating immune responses during viral infection.
  • Piglets treated with F. prausnitzii OMVs showed reduced viral load and improved clinical signs of PEDV, demonstrating the efficacy of microbial-derived therapies.
• Antibiotic treatment prior to the administration of F. prausnitzii OMVs enhanced their efficacy, indicating the importance of gut microbiota in mediating therapeutic effects against PEDV.
• The findings highlight how gut bacteria utilize OMVs to communicate and improve immune defense against viral pathogens.

Article: The microbiome-restorative potential of ibezapolstat for the treatment of Clostridioides difficile infection is predicted through variant PolC-type DNA polymerase III in Lachnospiraceae and Oscillospiraceae | Antimicrobial Agents and Chemotherapy

Summary

• Ibezapolstat demonstrates potential as a microbiome-restorative treatment option for patients suffering from Clostridioides difficile infections by selectively targeting the PolC-type DNA polymerase III in beneficial gut bacteria.
  1. Ibezapolstat (IBZ): A novel antibiotic
• The antibiotic's pharmacological effects may lead to an increased proportion of key beneficial gut microbiota, such as Lachnospiraceae and Oscillospiraceae.
  • Increased levels of beneficial gut microbes (Lachnospiraceae, Oscillospiraceae) have been observed in treated individuals, indicating a positive microbiome shift.
• Phase 2 clinical trials of ibezapolstat have exhibited a narrower than expected spectrum of activity, confirming its focused impact on low G + C bacterial pathogens while sparing healthy gut flora.
• Despite promising results, continued investigation into ibezapolstat’s effects on gut microbiota composition is essential for understanding its full therapeutic potential against CDI