r/Semaglutide • u/MaybePrestigious9485 • 2d ago

How come tirzepatide estimated weight loss is higher than semaglutide?

Which is better? What are the differences? I keep reading differing articles. Please share your thoughts! :)

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u/DaCozPuddingPop 2d ago

The 'better' one is the one that works for you.

The difference is that where semaglutide is a GLP1 agonist, tirz is also a GIP agonist - which reportedly will have more metabolic effect.

However, if semaglutide works for you, it works for you - I lost 70 pounds on sema with relative ease. Never felt a need to switch.

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u/MaybePrestigious9485 1d ago

That’s amazing! Congrats to you! 🥳 I don’t really need to lose so much or so quickly so I think sema is fine. The main thing I was thinking about is that the side effects are less bad with tirz? Is that true?

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u/DaCozPuddingPop 1d ago

It'll vary from person to person. They're both prone to very similar sides: constipation, diarrhea, nausea etc.

I would say try treating the side effects first before considering a switch, beit zofran for nausea or whatever else.